Study groups
The research physician about this research
In this clinical trial we will investigate how safe the study compound is and how well it is tolerated when it is used by healthy participants. We will also investigate how quickly and to what extent the study compound is absorbed, transported and eliminated by the body (this is called pharmacokinetics).
The study compound could potentially be used for the treatment of worsening heart failure. With worsening heart failure, the heart cannot pump the blood well enough anymore, resulting in blood and fluid collecting in the lungs and legs. Worsening of chronic heart failure is usually treated with diuretics, which are medicines that help reduce fluid buildup in the body, but do not fully resolve the congestion leaving the patients at risk of suffering new episodes of worsening heart failure and subsequent hospitalization. The study compound is aimed to relax the blood vessels, improve functioning of the heart and help the kidneys to remove water and salt.
Who can participate?
Note:
As a female you can only participate if you meet one of the following conditions:
As a male you can only participate if you meet one of the following conditions:
WHAT IS THE COMPENSATION FOR THIS RESEARCH?
Travelling expenses will be reimbursed based on the distance traveled (€ 0,19 net per kilometer) with a minimum of € 12,- and a maximum of € 160,- (840 kilometers) per round trip, regardless of the mode of transportation.
HOW LONG DOES THIS RESEARCH TAKE
The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 10 days (9 nights). The follow-up visit will take place between 21 and 23 days after your departure from the research facility.
Note: You must be available for all dates to be able to participate in this clinical trial.
You can participate in a trial a maximum of four times a year. There must be at least 30 days between two trials. Some trials have a longer waiting period.
During the trial, you may suffer from mild symptoms like headache or nausea. That may be caused by the medication. It might also be caused by needing to fast for the trial, for example. Those side effects are no fun, but fortunately are not dangerous.
Before a medication is tested on people, it has already been studied extensively in a lab. This enables us to predict well which side effects you might get and we can prepare you for them. It almost never happens that participants suffer from unexpected side effects. For example, an allergic reaction to the medication occurs on average once a year.
Your participation in a clinical trial is always voluntary. You can therefore decide to stop at any time. Sometimes you have to stop. For example because of family circumstances or if the doctor decides it is better for your health. If you stop, we will look at what portion of the compensation you are entitled to. It's only fair!