• You are a healthy female.
• You are at least 18 and at most 55 years old.
• Your weight is at least 45kg and at most 110 kg and your Body Mass Index (BMI) is at least 18.5 and at most 29.9 kg/m2. 
• You have not used any tobacco or nicotine containing products within six months prior to screening.

Note:

• You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the first compound administration in this clinical trial (counting from the follow-up visit).
• To determine if you are suitable to participate in this trial, you will undergo two separate screenings; one will be a medical screening, depending on availability, this can be performed in Groningen or in Utrecht. The second screening will be for a spirometry assessment, which will be performed in Groningen once you have passed the first medical screening.
  • Spirometry is where your lung function will be measured during the screening phase of the trial, using a special device in which you have to blow as hard as you can and as much as you can.

As a female you can only participate if you are not pregnant, not breast feeding and meet one of the following conditions from at least 4 weeks prior to the first administration of the study compound:

• You are using hormonal contraception (for example the contraceptive pill or intra-uterine device containing hormones) in combination with a condom;
• You are using a copper intra-uterine device in combination with a condom;
• You have passed the menopause (no periods for at least 12 months);
• You have been sterilized or your male partner has been sterilized;
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 12 days (11 nights). The follow-up visit will be telephonic and will take place within 7 days after your departure from the research facility.

Note: You must be available for all dates to be able to participate in this clinical trial.