• You are a healthy male or female.
• You are at least 18 and at most 60 years old.
• You weigh at least 40 kg (for females) / 50 kg (for males) and no more than 120 kg (for both males and females) and your Body Mass Index (BMI) is higher than or equal to 18.1 and lower than or equal to 31.9 kg/m2.
• Both non-smokers and light smokers (maximum of 5 cigarettes per day) are allowed to participate in this clinical trial. During your stay in our research facility you are not allowed to smoke.

Note:

• You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the first administration in this clinical trial (counting from the last administration).
• To determine if you are suitable to participate in this trial, you will undergo a medical screening. The medical screening consists of two separate visits. After the regular medical screening at ICON there will be an additional visit to perform an MRI scan.

As a female you can only participate if you are not pregnant, not breast feeding and meet one of the following conditions:

• You are using hormonal contraception (for example the contraceptive pill or intra-uterine device containing hormones);
• You have passed the menopause (no periods for at least 12 months);
• You have been sterilized or your male partner has been sterilized;
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

Please note: Copper IUD is not allowed due to the MRI-scan.

As a male you can only participate if you meet one of the following conditions:

• You are using a condom in combination with an additional contraception method used by your female partner;
• You have been sterilized or your female partner is sterilized or has passed the menopause (no periods for at least 12 months);
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 14 days (13 nights), followed by a minimum of 1 and a maximum of 3 short visits.

Following each short visit you will be contacted by telephone within 14 days to inform you whether another short visit is needed. During the short visit(s) a brain MRI-scan will be done. Although it is most likely that only the first short visit is necessary it is good to be aware that the total study length could be quite long if all short visits (3 in total) are needed. 

Note: You must be available for all dates to be able to participate in this clinical trial.