• You are a healthy male or female
• You are at least 18 and at most 49 years old.
• Your BMI (Body Mass Index) is between 18-30 kg/m². Your BMI is the ratio between your body weight (in kg) and your length (in m) taken squared.
• Your body weight is at least 60 kilos and at most 120 kilos.
• You have not smoked in the 4 weeks prior to the first study compound administration.

As a female you can only participate if you are not pregnant, not breastfeeding and meet one of the following conditions from the inspection until 90 days after the last dose:

• You use hormonal contraception (for example “the pill” or hormonal IUD);
• You use a copper coil;
• You have passed the menopause (no more periods for at least 12 months);
• You have been sterilized or your male partner has been sterilized;
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

​As a male you can only participate if you meet one of the following conditions:

• You use a condom with your female partner;
• You have been sterilized at least 3 months before the inspection or your female partner has been sterilized or has passed menopause (no more menstruations for at least 12 months);
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

Note:

• You cannot participate in the study if you have participated in another clinical study in the 30 days prior to the first compound administration in this clinical study (counting from the last compound administration in the previous study).
• To determine if you are suitable to participate in this study, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.

• In group 1 of this trial, every volunteer will stay in our clinic for 8 days (7 nights). After which you will come back for 1 short visit about a week after you leave the clinic.
• In group 2 of this trial, every volunteer will stay in our clinic for 7 days (6 nights). After which you will come back for 1 short visit about a week after you leave the clinic. 
• Approximately 3 weeks after your stay in our clinic, a follow up visit will take place. 
• If needed, you might be asked back for extra follow-up visits every 12 weeks after your follow up visit until no antibodies against the study compound are found in the blood. You will receive extra compensation for this visit as it is not part of the standard participation. It is good to note that the extra follow up visits are not mandatory.